A cancer breakthrough from scientists: A system developed that can make cancer cells self-destruct

Scientists have achieved a significant study that will facilitate the treatment of cancer cells. A system has been developed that will enable cancer cells to self-destruct.

According to a report by Emre Ömer Zehir from Webtekno, there are different types of drugs used in cancer treatment, but when it comes to affecting tumors, the efficacy of these drugs can be limited. One of the reasons for this is that drugs cannot reach the cancer cells clustered and concentrated in the inner parts of tumors. It has been noted that the new method discovered by scientists triggers the "self-destruct buttons" of cancer cells, opening gaps in the outer shell of tumors.

Fas, a receptor found in all cells, allows cells to self-destruct under certain conditions. To initiate this process, Fas receptors must be triggered with the correct antibodies. In other words, it was stated that eliminating a cell is more like inserting and turning the right key rather than just pressing the right button.

Researchers from the University of California, Davis and Indiana University focused on Fas receptors, which were previously viewed as "a structure whose value in cancer treatment was not fully understood." Despite previous research on Fas, none had reached the clinical trial stage.

FAILED PREVIOUSLY

In their recent studies on mouse models and human cells, researchers identified which antibodies bind to Fas receptors to trigger cell destruction. Despite studies previously considered unsuccessful, the researchers revealed which antibodies could bind to specific parts of the receptors, namely epitopes. The lead author of the study, Jogender Tushir-Smith, stated that this discovery shows that therapeutic treatments in tumors could be possible.

WILL BE ABLE TO FIGHT CANCER

If the vascular structures that keep the immune system out or the closed, solid cells that cause the definition of "cold tumors" are destroyed, cancer treatments such as CAR-T can be performed. It was stated that specially developed antibodies and antigens, which are normally ineffective because they cannot reach the diseased cell, can fight cancer by passing through the gaps opened by antibodies targeting Fas.

In the studies conducted, researchers managed to produce two antibodies that are "highly effective." These antibodies successfully triggered cells to self-destruct in many types of cancer, such as ovarian cancer. The researchers, who revealed two critically important parts of the Fas receptor, state that they could play an important role in future drug development studies. Furthermore, it was emphasized that if the antibodies used for CAR-T can also target the cells surrounding the tumor, significant progress could be made in the fight against cancer.

WILL BE ABLE TO ELIMINATE

Researchers say that by examining changes in Fas structures at the beginning of the patient's treatment process, customized antibodies can be developed. In this way, it was stated that cellular therapies such as CAR-T, which allow a person's own white blood cells to specifically target cancerous structures, could be more effective and could select and eliminate tumor cells.